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  • Risedronic Acid
Name:Risedronic Acid
CAS No:105462-24-6

PRODUCT DESCRIPTION

【Name】
Phosphonic acid,P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-
【CAS Registry number】
105462-24-6
【Synonyms】
Phosphonicacid, [1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (9CI)
1-Hydroxy-2-(3-pyridinyl)ethylidene bisphosphonic acid
1-Hydroxy-2-(3-pyridyl)ethylidene-1,1-diphosphonic acid
1-Hydroxy-2-pyrid-3-ylethylidene-1,1-bisphosphonic acid
BPH 2
NE 58019
Risedronate
【Molecular Formula】
C7H11NO7P2 (Products with the same molecular formula)
【Molecular Weight】
283.11
【Inchi】
InChI=1/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
【Canonical SMILES】
C1=CC(=CN=C1)CC(O)(P(=O)(O)O)P(=O)(O)[O-].[Na+]
【MOL File】
105462-24-6.mol

Chemical and Physical Properties

【Appearance】
white crystalline powder
【Density】
1.87 g/cm3
【Boiling Point】
692.3 °C at 760 mmHg
【Vapour】
4.03E-20mmHg at 25°C
【Refractive Index】
1.651
【Flash Point】
372.5 °C
【Solubilities】
Appearance:white crystalline powder
Transport Information:HAZARD 
Hazard Symbols:UN NO.
【Computed Properties】
Molecular Weight:305.094092 [g/mol]
Molecular Formula:C7H10NNaO7P2
H-Bond Donor:4
H-Bond Acceptor:8
Rotatable Bond Count:4
Exact Mass:304.983019
MonoIsotopic Mass:304.983019
Topological Polar Surface Area:151
Heavy Atom Count:18
Formal Charge:0
Complexity:375
Isotope Atom Count:0
Defined Atom Stereocenter Count:0
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:0
Undefined Bond Stereocenter Count:0
Covalently-Bonded Unit Count:2

Safety and Handling

【Hazard Codes】
UN NO.
【Transport】
HAZARD

Biomedical Effects and Toxicity

【Pharmacological Action】
- Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS.
- A class of drugs that act by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. Since they are inducers of vascular and other smooth muscle relaxation, they are used in the drug therapy of hypertension and cerebrovascular spasms, as myocardial protective agents, and in the relaxation of uterine spasms.

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